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integrin α v β 1  (R&D Systems)
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Galectin-induced cytokine secretion enhances expression of the endothelial cell surface adhesion molecules, which are responsible for galectin-mediated cancer cell-endothelial adhesion. ( A ) The presence of galectins induces expressions of cell surface adhesion molecules. Human micro-vascular lung endothelial cells were treated with control 1.5 μ g ml −1 BSA (red colour) or 1.5 μ g ml −1 galectins -2 (purple), -4 (brown), -8 (green), a combination of G-CSF (0.25 ng ml −1 ), IL-6 (0.15 ng ml −1 ), GRO α (1 ng ml −1 ), MCP-1 (1 ng ml −1 ) (black) for 24 h before the expressions of the HMVEC surface <t>integrin</t> α v β 1, VCAM-1, CD44 and E-selectin were analysed by flow cytometry. ( B ) The presence of neutralising antibodies against cell surface adhesion molecules inhibits galectins -2, -4 or -8-mediated cancer cell adhesion. Human micro-vascular lung endothelial cells were treated without or with 1.5 μ g ml −1 galectins -2, -4 or -8 for 24 h. The culture media were collected and used to assess ACA19 − cell adhesion to fresh HMVEC-Ls without or with addition of a combination of neutralising antibodies against integrin α v β 1 (10 μ g ml −1 ), CD44 (10 μ g ml −1 ), VCAM-1(10 μ g ml −1 ) and E-selectin (10 μ g ml −1 ). ** P <0.01, *** P <0.001 (ANOVA, Bonferroni).
Integrin α V β 1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Galectin-induced cytokine secretion enhances expression of the endothelial cell surface adhesion molecules, which are responsible for galectin-mediated cancer cell-endothelial adhesion. ( A ) The presence of galectins induces expressions of cell surface adhesion molecules. Human micro-vascular lung endothelial cells were treated with control 1.5 μ g ml −1 BSA (red colour) or 1.5 μ g ml −1 galectins -2 (purple), -4 (brown), -8 (green), a combination of G-CSF (0.25 ng ml −1 ), IL-6 (0.15 ng ml −1 ), GRO α (1 ng ml −1 ), MCP-1 (1 ng ml −1 ) (black) for 24 h before the expressions of the HMVEC surface integrin α v β 1, VCAM-1, CD44 and E-selectin were analysed by flow cytometry. ( B ) The presence of neutralising antibodies against cell surface adhesion molecules inhibits galectins -2, -4 or -8-mediated cancer cell adhesion. Human micro-vascular lung endothelial cells were treated without or with 1.5 μ g ml −1 galectins -2, -4 or -8 for 24 h. The culture media were collected and used to assess ACA19 − cell adhesion to fresh HMVEC-Ls without or with addition of a combination of neutralising antibodies against integrin α v β 1 (10 μ g ml −1 ), CD44 (10 μ g ml −1 ), VCAM-1(10 μ g ml −1 ) and E-selectin (10 μ g ml −1 ). ** P <0.01, *** P <0.001 (ANOVA, Bonferroni).

Journal: British Journal of Cancer

Article Title: Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis

doi: 10.1038/bjc.2013.793

Figure Lengend Snippet: Galectin-induced cytokine secretion enhances expression of the endothelial cell surface adhesion molecules, which are responsible for galectin-mediated cancer cell-endothelial adhesion. ( A ) The presence of galectins induces expressions of cell surface adhesion molecules. Human micro-vascular lung endothelial cells were treated with control 1.5 μ g ml −1 BSA (red colour) or 1.5 μ g ml −1 galectins -2 (purple), -4 (brown), -8 (green), a combination of G-CSF (0.25 ng ml −1 ), IL-6 (0.15 ng ml −1 ), GRO α (1 ng ml −1 ), MCP-1 (1 ng ml −1 ) (black) for 24 h before the expressions of the HMVEC surface integrin α v β 1, VCAM-1, CD44 and E-selectin were analysed by flow cytometry. ( B ) The presence of neutralising antibodies against cell surface adhesion molecules inhibits galectins -2, -4 or -8-mediated cancer cell adhesion. Human micro-vascular lung endothelial cells were treated without or with 1.5 μ g ml −1 galectins -2, -4 or -8 for 24 h. The culture media were collected and used to assess ACA19 − cell adhesion to fresh HMVEC-Ls without or with addition of a combination of neutralising antibodies against integrin α v β 1 (10 μ g ml −1 ), CD44 (10 μ g ml −1 ), VCAM-1(10 μ g ml −1 ) and E-selectin (10 μ g ml −1 ). ** P <0.01, *** P <0.001 (ANOVA, Bonferroni).

Article Snippet: Recombinant human galectins -2, -4 and -8 (residual endotoxin levels <1.0 EU μ g −1 protein), and human Cytokine Protein Array, antibodies against CD44, E-selectin, VCAM-1 and integrin α v β 1 were purchased from R&D Systems (Abingdon, UK).

Techniques: Expressing, Control, Flow Cytometry